Many problems are arising from the overuse of antibiotics: antibiotic resistance. This occurs when the antibiotic used has no effect or has lost the ability of killing and controlling bacteria. As a result bacteria are now able to multiply and grow in colonies inside the body with the presence of antibiotics. These bacteria that are capable of resisting antibiotics are known as: superbugs. In the worst case superbugs can lead to very severe cases. A 70 year old women living in US has died due to a superbug that was resistance to 26 different types of antibiotics. It had been further predicted in the US that superbugs may kill up to 300 million people by 2050. A quote provided by Bruce Geller from the Oregon State University ‘ We’ve lost the ability to use many of our mainstream antibiotics’. He has stated that antibiotic at this present stage has no effect on superbugs and bacteria resistant to antibiotics.
New Delhi Metallo-beta-lactamase (NDM-1).
New Delhi Metallo - beta - lactamase also known as (NDM - 10) is a gene found in the bacteria that produces an enzyme which destroys Beta - Lactam found in a class of antibiotics and penicillin. Furthermore other classes of antibiotics known as: Carbapenems are also destroyed by an enzyme: Carbapenemase - which further allows other classes of antibiotics to be immune to bacteria. Overuses of Carbapenems and antibiotics led to the development of NDM -1 enzymes in bacteria.
However scientists have now created a molecule that has the ability of reversing such bacteria that are immune to antibiotics. Even though they have modified antibiotics this has lead to the mutations of bacteria which were resisting even the modified versions of antibiotics. This specific type of molecule contains: Peptide Phosphorodiamidate mophino Oligomer (PPMO). This substance inhibits and destroys New Delhi Metallo - Beta - Lactamase (NDM - 1). A test trial was then conducted and was seen that it still had no effect as it was still producing NDM - 1.
When PPMO mixed with Meropenem ( a type of Carbapenem) it had a total reverse effect on bacteria being able to resist antibiotic. This was again tested on E.coli bacteria and was proven right that it was capable of destroying NDM -1 and bacteria were now not babe to resist antibiotics.
This is now ready and is currently undergoing intense clinical trials and tests and we can only see after if this is truly our answer to reversing antibiotic resistance